
It is a truism that the universe is entirely and intricately interconnected. Not withstanding all our collective efforts and technological achievements, as finite beings we cannot aspire to a “god
’s eye” perspective. We can barely begin to bring all events and all connections into view simultaneously.
For this reason a comprehensive understanding of ourselves and our world will always elude us. Our conjectures, poetic insights and most powerful scientific theories are—always—simplifications.
Polish born, British Mathematician and Polymath (1908-1974)

For Jacob Bronowski’s (1978: 69-70) the relationship between scientific endeavor and the truth hinges the notion that our conjectures always do violence to a “totally connected” universe:
Since… every fact has some influence on every other fact, then it follows that any cut you make at all is a convenient simplification. But in essence it is a distortion… it is natural that your decoding cannot be right. And it is not surprising that while you keep on getting approximate good answers (the answers get better and better as you progress because you exclude less and less), it is in principle out of the question that we should ever have an ultimate explanation. That would involve setting up experiments in which the whole of the universe was perceived from a God’s eye view.
Bronowski, Jacob (1978) The Origins of Knowledge and Imagination. Yale University Press, Princeton.